Purdue is now 1-0 all-time against Southeast Missouri as Saturday's contest was the first-ever meeting between the two schools.
Head Coach Danny Hope now owns a career record of 46-38, including a 11-16 mark at Purdue.
Purdue is now 82-29-3 all-time when playing an opponent for the first time. Southeast Missouri is the 114th school to play the Boilermakers in program history.
Purdue's 59-0 win is the largest margin of victory ever at Ross-Ade Stadium.
The Boilermakers finished with 627 yards of total offense, its highest total under Hope and most since Nov. 20, 2004 against Indiana.
The 393 yards rushing were Purdue's most since a 315-yard effort against Toledo on Sept. 5, 2009, and just shy of a 407-yard effort at Northwestern on Oct. 26, 2002.
Purdue's defense limited the Redhawks to just 153 yards of total offense. It was the first time the Boilermakers held an opponent under 200 yards since Sept. 11, 2004 (vs. Ball State), and the first game under 100 yards passing since Oct. 10, 2009 (at Minnesota).
The Boilermaker defense had 10 tackles for loss for 29 yards, including a pair of sacks.
The Boilermakers topped the 50-point plateau for the first time since Sept. 5, 2009 (52-31 vs. Toledo).
It was Purdue's first shutout since a 51-0 win vs. Syracuse on Sept. 5, 2004.
Purdue improved to 8-1 under Hope when rushing for over 200 yards, including 2-0 this season.
Purdue's 33 first downs were their most since Nov. 22, 2008 (35 vs. Indiana).