Purdue is now 26-54-2 all-time against Notre Dame, including a 10-25 record at Notre Dame Stadium.
Head Coach Danny Hope now owns a career record of 40-30, including a 5-8 mark at Purdue.
Boilermaker head coaches are now 4-13 in their career opener at Notre Dame.
Purdue is 1-2 all-time in season-openers against Notre Dame.
The Purdue defense posted its first safety since Sept. 2, 2006 vs. Indiana State.
The Boilermakers finished with 322 yards total offense, including 220 yards passing.
Robert Marve put in the Boilermakers' first touchdown of 2010, a 23-yard run in the fourth quarter.
Marve finished 31-for-42 passing, netting 220 yards and two interceptions.
Keith Smith logged a reception for the 25th consecutive game, finishing with 12 catches for 80 yards for the game. He's now tied for the nation's seventh longest active streak pending Saturday's results.
Saturday marked Smith's sixth career game with double-digit receptions.
Dan Dierking set single-game bests for rushing attempts, rushing yards and receptions, carrying nine times for 56 yards and hauling in five catches for 28 yards.
Ryan Kerrigan and Charlton Williams teamed for their first career safety. Kerrigan finished with seven tackles, including 2.5 for loss, a forced fumble and a sack.
Williams tied Kerrigan and Jason Werner for the high mark of seven tackles.
Logan Link had five tackles, including one for loss, and a fumble recovery in his first collegiate appearance.
Carson Wiggs scored the Boilermakers' first points of the 2010 season, hitting a 25-yard field goal in the second quarter.
Wiggs also tied his career-best punt of 51 yards on his first try of the day. He finished averaging 42.0 per punt, including two inside the 20.